An attempt to elucidate the mechanism of action of Fraxinus plant extract is that it increases the Bcl-2 expression, inhibits the translocation of mitochondrial apoptosis-inducing factor (AIF) to the cytoplasm, and decreases the Bax expression. Askr, the first man in Norse myth, literally means 'ash'. This plant has no children Legal Status. Sung et al., “Bioactive activities of natural products against herpesvirus infection,”, M. Alaniia, K. Shalashvili, T. Sagareishvili, N. Kavtaradze, and M. Sutiashvili, “Study of antioxidant activity of phenolic compounds from some species of Georgian flora,”, U. R. Chatterjee, S. S. Bandyopadhyay, D. Ghosh, P. K. Ghosal, and B. Ray, “In vitro anti-oxidant activity, fluorescence quenching study and structural features of carbohydrate polymers from Phyllanthus emblica,”, P. M. Guarrera, “Traditional antihelmintic, antiparasitic and repellent uses of plants in Central Italy,”, A. Azab, A. Nassar, and A. N. Azab, “Anti-inflammatory activity of natural products,”, E. Fasano, S. Serini, N. Mondella et al., “Antioxidant and anti-inflammatory effects of selected natural compounds contained in a dietary supplement on two human immortalized keratinocyte lines,”, M.-J. At low concentration (1–5 μM) it has direct protective effects and at higher concentration fraxetin activated the nuclear factor Nrf-2/ARE, which were linked with the increased activity of glutathione S-transferase-alpha and HO-1. The concern of resistance provoked the need of effective and eco-friendly alternatives [83]. He, Y. Lv, and G.-H. Du, “Esculin improves dyslipidemia, inflammation and renal damage in streptozotocin-induced diabetic rats,”, P. T. Thuong, Y. R. Pokharel, M. Y. Lee et al., “Dual anti-oxidative effects of fraxetin isolated from Fraxinus rhinchophylla,”, K. Xiao, Q.-H. Song, S.-W. Zhang, and L.-J. nov. associated with dieback of ash (Fraxinus excelsior) in Poland. The wood from European ash trees used … Sign up here as a reviewer to help fast-track new submissions. De Boer, “Traditional use of medicinal plants among Kalasha, Ismaeli and Sunni groups in Chitral District, Khyber Pakhtunkhwa province, Pakistan,”, M. Torres, O. Palomares, J. Quiralte, G. Pauli, R. Rodríguez, and M. Villalba, “An enzymatically active, J. F. Fernandez-Manjarres, P. R. Gerard, J. Dufour, C. Raquin, and N. Frascaria-Lacoste, “Differential patterns of morphological and molecular hybridization between Fraxinus excelsior L. and Fraxinus angustifolia Vahl (Oleaceae) in eastern and western France,”, S. R. Tanis and D. G. McCullough, “Host resistance of five fraxinus species to Agrilus planipennis (Coleoptera: Buprestidae) and effects of paclobutrazol and fertilization,”, D. D. Hinsinger, M. Gaudeul, A. Couloux, J. Bousquet, and N. Frascaria-Lacoste, “The phylogeography of Eurasian Fraxinus species reveals ancient transcontinental reticulation,”, P.-Q. Further research work is mandatory to fill the gaps by mainly focusing on the molecular targets of these plant extracts in extrinsic and intrinsic mitochondrial apoptosis pathways. JNK-1/2 mediated caspase activation induced the proteolysis of PKB and PARP, which leads to cell death [56]. Exogenous antioxidants primarily include natural as well as synthetic compounds having radical scavenging abilities. Fraxinus, a member of the Oleaceae family, commonly known as ash tree is found in northeast Asia, north America, east and western France, China, northern areas of Pakistan, India, and Afghanistan. Fraxinus plant has been accounted for its wide spectrum of biological activities including anticancer, anti-inflammatory, neuroprotective, antioxidant, anticytotoxic, antiaging, antimicrobial, and antihypertensive (Figure 1). Toxoplasmosis, an intracellular parasitic protozoan infection caused by Toxoplasma gondii, is usually asymptomatic but has serious clinical manifestations in immunocompromised individuals [100]. [10], Species are arranged into sections supported by phylogenetic analysis:[11][12], Unusual "treelets" growing from a fallen ash tree in Lawthorn Wood, Ayrshire, Scotland, North American native ash tree species are a critical food source for North American frogs, as their fallen leaves are particularly suitable for tadpoles to feed upon in ponds (both temporary and permanent), large puddles, and other water bodies. The mechanisms associated with antimicrobial action of fraxetin indicated the highest inhibition of topoisomerase-1 and topoisomerase 2 and remarkable increase in membrane permeability. This review reveals that Fraxinus plant is a valuable drug candidate with its potential anticarcinogenic, anti-inflammatory, antioxidative, and neuroprotective properties. It is also used as a tonic. Nuzhenide and GI3, the novel compounds from Fraxinus excelsior L. seed extract (FXE), decrease the systolic blood pressure significantly in spontaneously hypertensive rats (SHR) and obese Zucker rats at a dose concentration of 200 mg/kg [32]. 94 plant name records match your search criteria Fraxinus excelsior.The results are below. All … The hypoglycaemic effect of the aqueous extracts of Fraxinus excelsior (FE) seed and Silybum marianum (SM) aerial part was investigated in normal and streptozotocin (STZ) diabetic rats. The two most economically important species for wood production are white ash, in eastern North America, and European ash in Europe. Fraxetin (one of the main constituents of Fraxinus rhynchophylla) inhibitory effects against Staphylococcus aureus proliferation were investigated by treatment of bacterial cultures with fraxetin at a concentration of 0.05 mg/ml. This review reveals thatFraxinus plant is a valuable drug candidate with its potential anticarcinogenic, anti-inflammatory, antioxidative, and neuroprotective properties. Medicinal Plant Common Ash. Treatment of bacterial cultures (Staphylococcus aureus, Pseudomonas aeruginosa, Streptococcus lactis, Escherichia coli, and Mycobacterium phlei) with plant extracts using microplate resazurin assay for screening showed that Fraxinus pennsylvanicca exhibits notable antibacterial activities with MICs ranging from 62.5 to 1000 μg/ml [84]. The tree's common English name, "ash", traces back to the Old English æsc, which relates to the proto-Indo-European for the tree, while the generic name originated in Latin from a proto-Indo-European word for birch. [15] Lack of tannins in the American ash makes their leaves a good food source for the frogs, but also reduces its resistance to the ash borer. Rowans or mountain ashes have leaves and buds superficially similar to those of true ashes, but belong to the unrelated genus Sorbus in the rose family. Its robust structure, good looks, and flexibility combine to make ash ideal for staircases. More Accounts and Images; ARS … [16][17][18][19]. Woodworkers generally consider ash a "poor cousin" to the other major open pore wood, oak, but it is useful in any furniture application. Compounds isolated from various species of, Some of the biologically active compounds isolated from, A diagram representing the molecular targets and mechanism of action for, Department of Zoology, Faculty of Life Sciences, Government College University Faisalabad, Punjab 38000, Pakistan, Department of Zoology, Faculty of Life Sciences, University of Sargodha, Punjab 40100, Pakistan, Evidence-Based Complementary and Alternative Medicine, Antioxidant, anti-inflammatory, wound healing potential, Nuzhenide, GI3, GI5, ligstroside, oleoside 11-methyl ester, 1′′′-O-beta-D-glucosylformoside, excelsides A, excelsides B, oleoside dimethyl ester, coumarins, Antihypertensive, antihypertriglyceridemia, adipocyte differentiation inhibitory activity, antidiabetic, antihyperglycaemic, anti-inflammatory, antirheumatic, Hydroxyframoside B 2′′-hydroxyoleuropein, oleuropein, ligstroside, syringin, esculin, fraxetin, fraxetin-8-O-[11′-methyl-oleosidyl-(7′→ 6′′)]-beta-D-glucopyranoside, esculetin, Pancreatic lipase inhibitory activity, inhibitor of adipocyte differentiation in 3T3-L1 cells, neuroprotective (protection against Abeta (25–35)-induced neuronal toxicity), antidyslipidemia, renoprotective, metal and free radical induced LDL oxidation inhibitor, antiatherosclerosis, antioxidant, PTP1B inhibitor, antitoxoplasmosis, glutamate-induced neuronal HT-22 cell death inhibition, hepatoprotective, 7-epi-7-O-(E)-caffeoylloganic acid, griffithosides C, Abietane, C20-norabietane, 6, 7-di-O-beta-D-glucopyranosylesculetin, aromatic glycosides, plantasioside, Calceolarioside B, Esculetin, Antioxidant against DPPH radicals, antiphotoaging, quinone reductase (QR) inducing activity, Immunosuppressant (inhibition of IL-2 and IgE production in mouse spleen cells and U266 cells), Antioxidant, antifungal (MIC = 1.8–3.8 mg/mL), Anti-inflammatory against zymosan- and carrageenan-induced paw oedema, Analgesic, anti-inflammatory (superoxide scavenging effects on the xanthine-xanthine oxidase-cytochrome c system), Anti-inflammatory effect of oleuropein on LPS-induced BV-2 microglial cells, Protective effects of methanolic extract from, Modulation of cytokine expression by 5-methoxyl aesculetin (MOA) in LPS-stimulated RAW264.7 macrophages, Protective activities of methanolic extract of, T-cell activation⊥, arachidonic acid cascade⊥, Y. Luo, R. E. Cobb, and H. Zhao, “Recent advances in natural product discovery,”, A. Rasul, F. M. Millimouno, W. Ali Eltayb, M. Ali, J. Li, and X. Li, “Pinocembrin: a novel natural compound with versatile pharmacological and biological activities,”, A. L. Harvey, R. Edrada-Ebel, and R. J. Quinn, “The re-emergence of natural products for drug discovery in the genomics era,”, M. J. Balunas and A. D. Kinghorn, “Drug discovery from medicinal plants,”, A. G. Atanasov, B. Waltenberger, and E. M. Pferschy-Wenzig, “Discovery and resupply of pharmacologically active plant-derived natural products: a review,”, D. J. Newman and G. M. Cragg, “Natural products as sources of new drugs from 1981 to 2014,”, D. J. Newman, G. M. Cragg, and K. M. Snader, “Natural products as sources of new drugs over the period 1981–2002,”, T. Sen and S. K. Samanta, “Medicinal plants, human health and biodiversity: a broad review,”, N. Engel, A. Falodun, J. Kühn, U. Kragl, P. Langer, and B. Nebe, “Pro-apoptotic and anti-adhesive effects of four African plant extracts on the breast cancer cell line MCF-7,”, J. Paul, R. Gnanam, R. M. Jayadeepa, and L. Arul, “Anti cancer activity on graviola, an exciting medicinal plant extract vs various cancer cell lines and a detailed computational study on its potent anti-cancerous leads,”, V. Kuete, S. Alibert-Franco, K. O. Eyong et al., “Antibacterial activity of some natural products against bacteria expressing a multidrug-resistant phenotype,”, A. Mollataghi, E. Coudiere, A. H. A. Hadi et al., “Anti-acetylcholinesterase, anti-, M. Son, M. Lee, G.-H. Other creatures native to North America our aim is to update the scientific with! Especially in Europe. [ 29 ] pharmacodynamics and pharmacokinetics may also strengthen future.. Poor survival rates and small frog sizes blue ash ( Fraxinus excelsior Figure 1 the. Plants as alternative to synthetic fungicides is the spotlight issue nowadays [ 92 ] 2016, the first in! 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